Telomere Shortening in Alveolar Macrophages of Smokers and COPD Patients~!2010-02-18~!2010-03-05~!2010-04-15~!
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چکیده
منابع مشابه
Telomere Shortening in Alveolar Macrophages of Smokers and COPD Patients
Background: Tobacco smoking is reported to enhance telomere shortening in peripheral blood lymphocytes. However, telomere length of lung resident cells such as alveolar macrophages (AMs) has not been evaluated. Aim: We evaluated effect of tobacco smoking on telomere length in AMs. Methods: AMs were obtained from nine non-smokers (mean age 24.6 years, mean FEV1/FVC 93.8%) and ten healthy smokers...
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Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. Telomere length shortens with age in all replicating somatic cells. It has been shown that tobacco smoking enhances telomere shortening in circulating lymphocytes. The present study investigated whether this effect was further amplified in smokers who develop chronic obstructive pulmonary disease. Telomer...
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vs interferon (IFN)showed that IFNis superior to ADA, although the difference is small. Therefore, establishing a diagnosis of tuberculosis pleuritis based only on pleural fluid ADA without pleural biopsy findings is still controversial.6 We do not intend to deny the usefulness of pleural fluid ADA for diagnosing tuberculosis pleuritis. Furthermore, we do not insist that pleural fluid INFcan re...
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ژورنال
عنوان ژورنال: The Open Pathology Journal
سال: 2010
ISSN: 1874-3757
DOI: 10.2174/1874375701004010023